Porphyria cutanea tarda

Porphyria cutanea tarda (PCT) as a rule is the most common category of porphyria.
The disorder happens due to low levels of the enzyme accountable for the fifth step in heme creation. Heme is an important molecula for every body's organ. It's a part of hemoglobin and also facilitates transfer of oxygen in the blood.
Porphyria cutanea tarda fallout from underactivity of the enzyme uroporphyrinogen decarboxylase. Due to this begins store of porphyrins in the liver. Porhyrins manufactured in the liver are carried to the skin, using blood plasma as a transport.
Some precipitating factors can lead to the porphyria cutanea tarda. The most common of them are:
- an often alcohole use
- an extra iron in tissues
- using estrogens
- hepatitis c virus
Scientints think that all these thing influence on oxygen and iron in liver. So it can cause damage to the enzyme uroporphyrinogen decarboxylase.
In most cases people, who suffer from this disease, (something about 75-80%) do not have Porphyria cutanea tarda from heredity. Such form of PCT is called sporadic. In other cases the disease is hereditary and usually called familial. Both forms happens in an about 1 in 25 thouthands people.
The symptoms of Porphyria cutanea tarda usually become visible in maturity. The skin becoming overly precise to sunlight. Places of skin exposed to the sun become blisterring and scarring. It can also change pigmentation. Sometimes an augmented growth of hair occurs. Such areas of skin have a greater risk of an abnormal functionality of a liver and cancer.
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